The interface to theexecutable human.
OpenBody is an open, model-neutral protocol for discovering, querying, simulating and exchanging uncertainty-aware computational representations of human biological state.
Healthcare today records what happened. Tomorrow it models what happens next.
The EHR is primarily an event ledger and workflow engine. It provides observations to a clinician, who reconstructs the important model of the patient internally.
OpenBody moves that model into a continuously calibrated computational substrate: what is observed, what is inferred, what is uncertain, where the system is heading, and what a proposed intervention might change.
The hospital no longer needs to reconstruct the patient from scattered records. With permission, it can interrogate the patient's living model.
Seven planes. One computational body.
OpenBody sits above existing health-data standards. FHIR, DICOM, IEEE 11073 and GA4GH remain authoritative for their domains; OpenBody standardizes the computational semantics above them.
Observation Plane
Source-grounded measurements and events: ECG, CGM, labs, imaging, genomics, medication, symptoms and environment.
State Plane
What we currently believe about the body — explicitly temporal, evidence-linked and uncertainty-aware.
Model Plane
Discoverable statistical, causal, mechanistic, PK/PD, physiological, cellular and hybrid models.
Simulation Plane
Execute counterfactual perturbations and compare plausible futures before touching the real human.
Evidence Plane
Every computational claim carries provenance, epistemic class, uncertainty, applicability and abstention semantics.
Authority Plane
Reasoning and action remain separate. A model may propose; authorization governs what may actually happen.
Federation Plane
The best cardiac, metabolic or genomic model can come from different providers and evolve independently.
Not one model. A federation of specialists.
A person's twin can combine the best available model for each biological subsystem, from molecular and cellular dynamics to organ physiology and whole-body coupling.
Observe → understand → predict → simulate → intervene → measure → learn.
POST /v1/simulations
{
"subject": "subject:local-demo",
"perturbation": {
"kind": "behavior",
"description": "Walk 15 min after dinner"
},
"requested_scopes": [
"ob://human/metabolic/glucose_regulation"
],
"horizon_seconds": 7200
}Abstention is a first-class result.
If subject, evidence, model capability, biological scope, horizon, provenance or authority cannot be proven, OpenBody does not improvise. It returns an explicit governed abstention.
A coordinate system for the computational human.
OpenBody Coordinates give models, evidence, state and perturbations a common way to say where in the human they apply.
Person. Biology. Authority.
OpenBody is one layer in a broader architecture for AI systems that reason about and act for a human without collapsing identity, biology and authority into one unsafe interface.
OpenMind
Identity, memory, preferences, goals, experience and context.
OpenBody
State, evidence, biological models, trajectories and simulation.
Mandamus
Delegation, authorization, consent and governed action.
The record is evidence. The twin is the model.
OpenBody is building the interoperable runtime between humans, digital twins, frontier biological models, AI systems and clinical infrastructure.